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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA2 All Species: 4.55
Human Site: S2158 Identified Species: 8.33
UniProt: Q9BZC7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZC7 NP_001597 2435 269873 S2158 Y T R L R G I S W K D E A R V
Chimpanzee Pan troglodytes XP_001152577 2346 264166 A2072 T S G V A T V A G K S I L T N
Rhesus Macaque Macaca mulatta XP_001117819 2476 273629 S2185 Y T R L R G I S W K D E A R V
Dog Lupus familis XP_537788 2395 264756 P2110 Y T R L R G I P W K D E A R V
Cat Felis silvestris
Mouse Mus musculus P41234 2434 270490 P2159 Y T R L R G I P W K D E A Q V
Rat Rattus norvegicus Q9ESR9 2434 270910 P2159 Y T R L R G I P W K D E A Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 L2006 F D A I N E L L T G R E H V E
Chicken Gallus gallus XP_422330 2276 256293 L2016 Y C P Q F D A L D D L L T G R
Frog Xenopus laevis NP_001089022 2363 267334 D2100 T G Y C P Q F D A L D D L L T
Zebra Danio Brachydanio rerio NP_001139161 2268 254351 L2008 F D A I N D L L T G R E H L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 E1444 I G G R D V T E L I S I G Y C
Sea Urchin Strong. purpuratus XP_798273 1913 213253 F1653 L P A V I I L F L L Y G F S I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 D1621 D E P S T G M D P V A K R F M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.1 96 82.2 N.A. 91 92.9 N.A. 39.1 35.7 36.5 37.7 N.A. N.A. N.A. 23.7 41.7
Protein Similarity: 100 52 96.6 86.1 N.A. 93.2 94.9 N.A. 55.7 53.5 54.7 54.5 N.A. N.A. N.A. 39 54.4
P-Site Identity: 100 6.6 100 93.3 N.A. 86.6 86.6 N.A. 6.6 6.6 6.6 6.6 N.A. N.A. N.A. 0 0
P-Site Similarity: 100 33.3 100 93.3 N.A. 93.3 93.3 N.A. 26.6 6.6 13.3 26.6 N.A. N.A. N.A. 0 20
Percent
Protein Identity: N.A. N.A. N.A. 26.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 24 0 8 0 8 8 8 0 8 0 39 0 0 % A
% Cys: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 16 0 0 8 16 0 16 8 8 47 8 0 0 0 % D
% Glu: 0 8 0 0 0 8 0 8 0 0 0 54 0 0 16 % E
% Phe: 16 0 0 0 8 0 8 8 0 0 0 0 8 8 0 % F
% Gly: 0 16 16 0 0 47 0 0 8 16 0 8 8 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % H
% Ile: 8 0 0 16 8 8 39 0 0 8 0 16 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 47 0 8 0 0 0 % K
% Leu: 8 0 0 39 0 0 24 24 16 16 8 8 16 16 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 8 16 0 8 0 0 24 8 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 8 0 0 0 0 0 0 0 16 0 % Q
% Arg: 0 0 39 8 39 0 0 0 0 0 16 0 8 24 8 % R
% Ser: 0 8 0 8 0 0 0 16 0 0 16 0 0 8 0 % S
% Thr: 16 39 0 0 8 8 8 0 16 0 0 0 8 8 8 % T
% Val: 0 0 0 16 0 8 8 0 0 8 0 0 0 8 39 % V
% Trp: 0 0 0 0 0 0 0 0 39 0 0 0 0 0 0 % W
% Tyr: 47 0 8 0 0 0 0 0 0 0 8 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _